Article

Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Large language models and generative protein design promise to accelerate biotechnology, but it remains unclear whether they can engineer dynamic megasynth(et)ases whose activity depends on transient, context-specific domain interfaces. Non-ribosomal peptide synthetases (NRPSs) exemplify this challenge and produce many clinically used therapeutics. Here we integrate pretrained generativ...

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Literature Corpus work: 3079a588-d82a-5f8e-a36d-683016513369
DOI: 10.21203/rs.3.rs-9138214/v1

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