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Article

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.

Nature cell biology - 1 Jul 2015

Hu Guowu, McQuiston Travis, Bernard Amélie, Park Yoon-Dong, Qiu Jin, Vural Ali, Zhang Nannan, Waterman Scott R, Blewett Nathan H, Myers Timothy G, Maraia Richard J, Kehrl John H, Uzel Gulbu, Klionsky Daniel J, Williamson Peter R

Abstract excerpt

Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under nutrient-replete conditions, Dcp2 undergoes TOR-dependent phosphorylation and associates with RCK members to form a...

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Identifiers

PMID: 26098573
DOI: 10.1038/ncb3189
PMCID: PMC4528364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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