Article
Crystal structure of Dcp1p and its functional implications in mRNA decapping.
Nature structural & molecular biology - 1 Mar 2004
She Meipei, Decker Carolyn J, Sundramurthy Kumar, Liu Yuying, Chen Nan, Parker Roy, Song Haiwei
Abstract excerpt
A major pathway of eukaryotic mRNA turnover begins with deadenylation, followed by decapping and 5'-->3' exonucleolytic degradation. A critical step in this pathway is decapping, which is carried out by an enzyme composed of Dcp1p and Dcp2p. The crystal structure of Dcp1p shows that it markedly resembles the EVH1 family of protein domains. Comparison of the proline-rich sequence (PRS)-binding sites in this family...
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