Article

Mechanistic Insights into Proteomic Mutation-Phenotype Linkages from Tiling Mutagenesis Screens

2025-04-23

Abstract excerpt

<h4>ABSTRACT</h4> High-throughput mutagenesis screens are powerful tools for mapping mutations to phenotypes. However, deciphering the molecular mechanisms that link mutations to phenotypic outcomes remains a significant challenge. Here, we present ProTiler-Mut, a versatile computational framework that harnesses tiling mutagenesis screens, which introduce variants across entire protein sequences, to facilitate in...

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Literature Corpus work: 2c55908a-3838-5f01-89a5-9b579de9cb1a
DOI: 10.1101/2025.04.17.649336

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