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Article

Protein structural context of cancer mutations reveals molecular mechanisms and candidate driver genes.

Cell reports - 26 Nov 2024

Chillón-Pino Diego, Badonyi Mihaly, Semple Colin A, Marsh Joseph A

Abstract excerpt

Advances in protein structure determination and modeling allow us to study the structural context of human genetic variants on an unprecedented scale. Here, we analyze millions of cancer-associated missense mutations based on their structural locations and predicted perturbative effects. By considering the collective properties of mutations at the level of individual proteins, we identify distinct patterns...

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PMID: 39441719
DOI: 10.1016/j.celrep.2024.114905

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