Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance.

Signal transduction and targeted therapy - 19 Mar 2025

Liu Ying, Liu Yongshuo, Niu Xuran, Chen Ang, Li Yizhou, Yu Ying, Mo Binrui, Liu Zhiheng, Xu Tao, Cheng Jie, Wu Zeguang, Wei Wensheng

Abstract excerpt

Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic efficacy. Somatic mutations in cancer cells that modulate these critical regulators are closely associated with tumor progression and ICB response. However, a systematic interpretation of cancer immune-related mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer Immunotherapy and Biomarkers

Share to Cell Line, Tumor

Share to Gene Expression Regulation, Neoplastic

Share to Immunologic Surveillance

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40102418
DOI: 10.1038/s41392-025-02171-5
PMCID: PMC11920242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance.PMID 40102418Read ↗

Massively parallel interrogation of human functional variants modulating cancer immunosurveillanceSemantic proximity Read ↗

Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cellsSemantic proximity Read ↗

TMBpred: A bioinformatics tool for precise prediction of the Tumor Mutation Burden in 14 cancer typesSemantic proximity Read ↗

Genome-wide analysis of somatic noncoding mutation patterns in cancer.Semantic proximity Read ↗

Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatmentSemantic proximity Read ↗

HLA Typing and Mutation Calling from Normal and Tumor Whole Genome Sequencing Data with ALPHLARD-NT.Semantic proximity Read ↗

Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.Semantic proximity Read ↗

INAEME: Integral Neoantigen Analysis with Entirety of Mutational EventsSemantic proximity Read ↗

Landscape and functional impact of missense mutations of immune response genes in human cancerSemantic proximity Read ↗

Advances in Precision Oncology: From Molecular Profiling to Regulatory-Approved Targeted TherapiesSemantic proximity Read ↗

Landscape and functional impact of variants of unknown significance of immune response genes in human cancer.Semantic proximity Read ↗

Variable Mutation Expression in Human Cancers: A "Hide-and-Seek" Mechanism Linked to Differential MHC-I Presentation Dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.