Article

Mutation Impact on mRNA Versus Protein Expression across Human Cancers

2023-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Cancer mutations are often assumed to alter proteins, thus promoting tumorigenesis. However, how mutations affect protein expression has rarely been systematically investigated. We conduct a comprehensive analysis of mutation impacts on mRNA- and protein-level expressions of 953 cancer cases with paired genomics and global proteomic profiling across six cancer types. Protein-level impacts are va...

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Literature Corpus work: c087125f-4bfd-5936-809a-104108119442
DOI: 10.1101/2023.11.13.566942

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