Article

EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic fusions of EML4 and ALK occur in ∼5% of lung adenocarcinomas. More than 15 EML4-ALK variants with distinct breakpoints within EML4 have been identified, but the functional differences between these variants remain poorly understood. Here we use CRISPR/Cas9 somatic genome editing to generate autochthonous mouse models of the two most common EML4-ALK variants, V1 and V3, and show that V...

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Literature Corpus work: 2c377f3a-2299-521e-9d04-73f8a13171c3
DOI: 10.1101/2024.08.26.609730

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