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Article

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Nature communications - 10 Oct 2017

Ma Pengfei, Fu Yujie, Cai Mei-Chun, Yan Ying, Jing Ying, Zhang Shengzhe, Chen Minjiang, Wu Jie, Shen Ying, Zhu Liang, Chen Hong-Zhuan, Gao Wei-Qiang, Wang Mengzhao, Gu Zhenyu, Bivona Trever G, Zhao Xiaojing, Zhuang Guanglei

Abstract excerpt

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline and environmental background. We find that...

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Identifiers

PMID: 29018192
DOI: 10.1038/s41467-017-00963-0
PMCID: PMC5634994

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