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Designed miniproteins potently inhibit and protect against MERS-CoV

30 May 2025

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen with a 36% case-fatality rate in humans. No vaccines or specific therapeutics are currently approved for use in humans or the camel host reservoir. Here, we computationally designed monomeric and homo-oligomeric miniproteins that bind with high affinity to the MERS-CoV spike (S) glycoprotein, the main target of neutralizing antibodies...

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Identifiers

PMID: 40450691
DOI: 10.1016/j.celrep.2025.115760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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