Article

Designed miniproteins potently inhibit and protect against MERS-CoV

2024-11-04

Abstract excerpt

Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen with 36% case-fatality rate in humans. No vaccines or specific therapeutics are currently approved to use in humans or the camel host reservoir. Here, we computationally designed monomeric and homo-oligomeric miniproteins binding with high affinity to the MERS-CoV spike (S) glycoprotein, the main target of neutralizing antibodies and va...

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Identifiers and source

Literature Corpus work: 009410b2-661f-534b-b6b5-4e617cb80b4a
DOI: 10.1101/2024.11.03.621760

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