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Article

Polygenic Prediction of Type 2 Diabetes in Africa.

Diabetes care - 1 Mar 2022

Chikowore Tinashe, Ekoru Kenneth, Vujkovi Marijana, Gill Dipender, Pirie Fraser, Young Elizabeth, Sandhu Manjinder S, McCarthy Mark, Rotimi Charles, Adeyemo Adebowale, Motala Ayesha, Fatumo Segun

Abstract excerpt

OBJECTIVE: Polygenic prediction of type 2 diabetes (T2D) in continental Africans is adversely affected by the limited number of genome-wide association studies (GWAS) of T2D from Africa and the poor transferability of European-derived polygenic risk scores (PRSs) in diverse ethnicities. We set out to evaluate if African American, European, or multiethnic-derived PRSs would improve polygenic prediction in...

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Identifiers

PMID: 35015074
DOI: 10.2337/dc21-0365
PMCID: PMC8918234

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