Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lean ZSF1 Rats in Basic Research on Heart Failure with Preserved Ejection Fraction

11 Dec 2024

Abstract excerpt

AIMS: ) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research. Studies using ZSF1 rats have contributed significantly to the elucidation of pathophysiological mechanisms underlying HFpEF and therapeutic strategies against this multi-organ syndrome. In contrast, hybrid, lean ZSF1 rats (L-ZSF1) do not develop HFpEF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Heart Failure Treatment and Management
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39663741
DOI: 10.1002/ehf2.15111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lean ZSF1 Rats in Basic Research on Heart Failure with Preserved Ejection FractionPMID 39663741Read ↗

Cardiometabolic Phenotype in HFpEF: Insights from Murine ModelsSemantic proximity Read ↗

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)Semantic proximity Read ↗

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15Semantic proximity Read ↗

Noncoding and Coding Mechanisms of Aging Heart Failure with Preserved Ejection Fraction with Thyroid DysfunctionSemantic proximity Read ↗

<i>ALMS1</i> KO rat: a new model of metabolic syndrome with spontaneous hypertensionSemantic proximity Read ↗

Simultaneous characterization of metabolic, cardiac, vascular and renal phenotypes of lean and obese SHHF rats.Semantic proximity Read ↗

A matter of food and substrain: obesogenic diets induce differential severity of cardiac remodeling and diastolic dysfunction in C57Bl/6J and C57Bl/6N substrainsSemantic proximity Read ↗

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read ↗

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertensionSemantic proximity Read ↗

Next Generation of Spontaneously Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop Cardiac Dysfunction and Compromised Cardiac ReserveSemantic proximity Read ↗

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesitySemantic proximity Read ↗

Proteomic and structural heart changes in obese rats are incompletely restored after weight lossSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.