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Article

Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.

The Journal of clinical endocrinology and metabolism - 1 Aug 2006

Minton J A L, Owen K R, Ricketts C J, Crabtree N, Shaikh G, Ehtisham S, Porter J R, Carey C, Hodge D, Paisey R, Walker M, Barrett T G

Abstract excerpt

CONTEXT: Alström syndrome (AS) is a monogenic form of infancy-onset obesity and insulin resistance, caused by ALMS1 mutations. The natural history of the insulin resistance is unknown, in particular how this relates to changes in body composition. It is also unclear how ALMS1 mutations relate to the characteristic phenotype. OBJECTIVES: Our objectives were to characterize body composition and metabolic...

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Identifiers

PMID: 16720663
DOI: 10.1210/jc.2005-2633

Genes

ALMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.PMID 16720663Read ↗

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