Article

Genomic knockout of <i>alms1</i> in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes

2018-10-10

Abstract excerpt

<h4>SCIENTIFIC ABSTRACT</h4> Alström syndrome is an autosomal recessive obesity ciliopathy caused by loss-of-function mutations in the ALMS1 gene. In addition to multi-organ dysfunction, such as cardiomyopathy, retinal degeneration, and renal dysfunction, the disorder is characterized by high rates of obesity, insulin resistance and early onset type 2 diabetes mellitus (T2DM). To investigate mechanisms linking d...

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Literature Corpus work: 60d094fe-5cf2-50e2-89a5-2f0717666fbc
DOI: 10.1101/439067

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