Article
Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice.
Endocrinology - 1 Jul 2016
Talton Omonseigho O, Pennington Kathleen A, Pollock Kelly E, Bates Keenan, Ma Lixin, Ellersieck Mark R, Schulz Laura C
Abstract excerpt
Maternal obesity and gestational diabetes are prevalent worldwide. Offspring of mothers with these conditions weigh more and are predisposed to metabolic syndrome. A hallmark of both conditions is maternal hyperleptinemia, but the role of elevated leptin levels during pregnancy on developmental programming is largely unknown. We previously found that offspring of hyperleptinemic mothers weighed less and had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.