Article

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

2019-02-14

Abstract excerpt

Accumulating somatic mutations have been implicated in age-related cellular degeneration and death. Because of their random nature and low abundance, somatic mutations are difficult to detect except in single cells or clonal lineages. Here we show that in single hepatocytes from human liver, an organ normally exposed to high levels of genotoxic stress, somatic mutation frequencies are high and increase substantial...

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Literature Corpus work: 2c1583ad-c52d-531e-ae6b-f2e47ec771b0
DOI: 10.1101/547893

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