Article
Mitigating age-related somatic mutation burden.
Trends in molecular medicine - 1 Jul 2023
Vijg Jan, Schumacher Björn, Abakir Abdulkadir, Antonov Michael, Bradley Chris, Cagan Alex, Church George, Gladyshev Vadim N, Gorbunova Vera, Maslov Alexander Y, Reik Wolf, Sharifi Samim, Suh Yousin, Walsh Kenneth
Abstract excerpt
Genomes are inherently unstable and require constant DNA repair to maintain their genetic information. However, selective pressure has optimized repair mechanisms in somatic cells only to allow transmitting genetic information to the next generation, not to maximize sequence integrity long beyond the reproductive age. Recent studies have confirmed that somatic mutations, due to errors during genome repair and...
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