Article
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity.
Nature aging - 1 Aug 2022
Choudhury Sangita, Huang August Yue, Kim Junho, Zhou Zinan, Morillo Katherine, Maury Eduardo A, Tsai Jessica W, Miller Michael B, Lodato Michael A, Araten Sarah, Hilal Nazia, Lee Eunjung Alice, Chen Ming Hui, Walsh Christopher A
Abstract excerpt
The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in 56 single cardiomyocytes from 12 individuals (aged from 0.4 to 82 years). Cardiomyocyte sSNVs...
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