Article

Solvent-induced allosteric transition of the Hepatitis C virus human cellular receptor CD81 large extracellular loop

2022-03-21

Abstract excerpt

CD81 is a tetraspanin receptor that clusters into microdomains to mediate cell signalling processes. CD81 is also one of the four primary cellular receptors of the Hepatitis C virus (HCV). Previous structural studies on the α-helical CD81 large-extracellular-loop domain (CD81 LEL ) have shown that it can adopt different conformations (from closed to open), likely depending on the environmental conditions. This co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2bfa7ab5-e0f3-54bd-94cb-1812cd4eb3b4
DOI: 10.1101/2022.03.21.485124

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Solvent-induced allosteric transition of the Hepatitis C virus human cellular receptor CD81 large extracellular loopDOI 10.1101/2022.03.21.485124Read

Cholesterol sensing by CD81 is important for hepatitis C virus entrySemantic proximity Read

An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry.Semantic proximity Read

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells.Semantic proximity Read

ACIDIC BICELLES ARE A SUITABLE MEMBRANE MIMIC FOR STRUCTURAL STUDIES OF THE LASSA VIRUS FUSION DOMAINSemantic proximity Read

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activitySemantic proximity Read

Conserved Transmembrane Asparagine Is Essential for the Ion-Conducting Structure and Dynamics of the SARS-CoV-2 Envelope Protein.Semantic proximity Read

Polar Networks Mediate Ion Conduction of the SARS-CoV-2 Envelope Protein.Semantic proximity Read

Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigenSemantic proximity Read

A conserved H-bond network in human aquaporin-1 is necessary for native folding and oligomerization.Semantic proximity Read

Molecular modeling of transmembrane helices 6 and 7 of the heptahelical lutropin receptor.Semantic proximity Read

Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif.Semantic proximity Read

Helical integrity and microsolvation of transmembrane domains from Flaviviridae envelope glycoproteins.Semantic proximity Read