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Article

Conserved Transmembrane Asparagine Is Essential for the Ion-Conducting Structure and Dynamics of the SARS-CoV-2 Envelope Protein.

Journal of the American Chemical Society - 14 Jan 2026

Asadollahi Kazem, Medeiros-Silva João, Wagner Paul A, Hong Mei

Abstract excerpt

The envelope (E) protein of the SARS coronavirus forms a pathogenic cation-selective channel across intracellular membranes. The ion-conduction mechanism of the hydrophobic transmembrane domain of the protein, ETM, has been elusive despite recent determination of its high-resolution structures in the closed and open states. Here, we investigate the structural mechanism of SARS ETM by mutating two residues, T11...

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Identifiers

PMID: 41420568
DOI: 10.1021/jacs.5c18146
PMCID: PMC12961957

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