Article
CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells.
Viruses - 20 Apr 2018
Banse Pia, Moeller Rebecca, Bruening Janina, Lasswitz Lisa, Kahl Sina, Khan Abdul G, Marcotrigiano Joseph, Pietschmann Thomas, Gerold Gisa
Abstract excerpt
Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop (LEL), which interacts with the E2 glycoprotein of HCV. The role of the non-LEL regions of hCD81 (intracellular tails, four transmembrane domains, small extracellular loop and intracellular loop) is poorly understood. Here, we studied...
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