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Article

A conserved H-bond network in human aquaporin-1 is necessary for native folding and oligomerization.

Biophysical journal - 17 Dec 2024

Drewniak Philip, Xiao Peng, Ladizhansky Vladimir, Bondar Ana-Nicoleta, Brown Leonid S

Abstract excerpt

Aquaporins (AQPs) are α-helical transmembrane proteins that conduct water through membranes with high selectivity and permeability. For human AQP1, in addition to the functional Asn-Pro-Ala motifs and the aromatic/Arg selectivity filter within the pore, there are several highly conserved residues that form an expansive hydrogen-bonding network. Previous solid-state nuclear magnetic resonance studies and...

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Identifiers

PMID: 39425471
DOI: 10.1016/j.bpj.2024.10.011
PMCID: PMC11700357

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