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Article

Polar Networks Mediate Ion Conduction of the SARS-CoV-2 Envelope Protein.

Journal of the American Chemical Society - 8 Jan 2025

Medeiros-Silva João, Pankratova Yanina, Sučec Iva, Dregni Aurelio J, Hong Mei

Abstract excerpt

The SARS-CoV-2 E protein conducts cations across the cell membrane to cause pathogenicity to infected cells. The high-resolution structures of the E transmembrane domain (ETM) in the closed state at neutral pH and in the open state at acidic pH have been determined. However, the ion conduction mechanism remains elusive. Here, we use solid-state NMR spectroscopy to investigate the side chain structure, dynamics,...

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Identifiers

PMID: 39726395
DOI: 10.1021/jacs.4c13229
PMCID: PMC12226150

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