Article
A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei.
G3 (Bethesda, Md.) - 11 Apr 2014
Jovelin Richard, Comstock Jennifer S, Cutter Asher D, Phillips Patrick C
Abstract excerpt
The discovery that genetic pathways can be manipulated to extend lifespan has revolutionized our understanding of aging, yet their function within natural populations remains poorly characterized. In particular, evolutionary theories of aging predict tradeoffs in resource investment toward somatic maintenance vs. reproductive output that should impose strong natural selection on genetic components that influence...
Topics
- Aging
- Animals
- Biological Evolution
- Caenorhabditis
- Genetic Loci
- Genetic Variation
- Genetics, Population
- Insulin
- Models, Biological
- Molecular Sequence Data
- Phosphatidylinositol 3-Kinases
- Polymorphism, Single Nucleotide
- Selection, Genetic