Article

Structure of the human pro-myostatin precursor and determinants of growth factor latency

2017-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent precursor in muscle and is activated by sequential proteolysis of the pro-domain. To investigate the molecular mechanism by which pro-myostatin remains latent, we have solved the structure of unprocessed promyostatin and analysed the properties of the protein in its different forms. Crystal structures and SAX...

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Literature Corpus work: 2be89145-ec5d-5990-8cee-b439776c1618
DOI: 10.1101/153403

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