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Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?

31 Aug 2020

Abstract excerpt

Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly, loss-of-function mutations in myostatin result in a dramatic increase in muscle mass in humans and various animals, while its overexpression leads to severe muscle atrophy. Myostatin also exerts a significant effect on bone...

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PMID: 32911580
DOI: 10.11005/jbm.2020.27.3.151

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