Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects.

Abstract excerpt

Since its identification in 1997, myostatin has been considered as a novel and unique negative regulator of muscle growth, as mstn-/- mice display a dramatic and widespread increase in skeletal muscle mass. Myostatin also appears to be involved in muscle homeostasis in adults as its expression is regulated during muscle atrophy. Moreover, deletion of the myostatin gene seems to affect adipose tissue mass in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression
• Share to Muscle Development