Article
Latent TGF-β structure and activation.
Nature - 15 Jun 2011
Shi Minlong, Zhu Jianghai, Wang Rui, Chen Xing, Mi Lizhi, Walz Thomas, Springer Timothy A
Abstract excerpt
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of α(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins. Crystals of dimeric porcine proTGF-β1 reveal a ring-shaped complex, a novel fold for the...
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