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Biochemistry and Biology of GDF11 and Myostatin

31 Mar 2016

Abstract excerpt

Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related members of the transforming growth factor β superfamily and are often perceived to serve similar or overlapping roles. Yet, despite commonalities in protein sequence, receptor utilization and signaling, accumulating evidence suggests that these 2 ligands can have distinct functions in many situations. GDF11 is essential for...

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PMID: 27034275
DOI: 10.1161/circresaha.116.308391

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