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Article

Characterization of tolloid-mediated cleavage of the GDF8 procomplex.

The Biochemical journal - 14 May 2021

McCoy Jason C, Goebel Erich J, Thompson Thomas B

Abstract excerpt

Growth differentiation factor 8 (GDF8), a.k.a. myostatin, is a member of the larger TGFβ superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of muscle mass. After synthesis, GDF8 is held latent by a noncovalent complex between the N-terminal prodomain and the signaling ligand. Activation of latent GDF8 requires proteolytic cleavage of the prodomain at residue D99 by a member...

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Identifiers

PMID: 33876824
DOI: 10.1042/BCJ20210054
PMCID: PMC8670536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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