Article
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.
Nature genetics - 1 Apr 2023
Hou Kangcheng, Ding Yi, Xu Ziqi, Wu Yue, Bhattacharya Arjun, Mester Rachel, Belbin Gillian M, Buyske Steve, Conti David V, Darst Burcu F, Fornage Myriam, Gignoux Chris, Guo Xiuqing, Haiman Christopher, Kenny Eimear E, Kim Michelle, Kooperberg Charles, Lange Leslie, Manichaikul Ani, North Kari E, Peters Ulrike, Rasmussen-Torvik Laura J, Rich Stephen S, Rotter Jerome I, Wheeler Heather E, Wojcik Genevieve L, Zhou Ying, Sankararaman Sriram, Pasaniuc Bogdan
Abstract excerpt
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. This offers the unique opportunity of investigating the similarity of genetic effects on traits across ancestries within the same population. Here we introduce an approach to estimate correlation of causal genetic effects (radmix)...
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