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Article

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications.

American journal of human genetics - 2 Oct 2025

Dias Julie-Alexia, Chen Tony, Xing Hua, Wang Xiaoyu, Rodriguez Alex A, Madduri Ravi K, Kraft Peter, Zhang Haoyu

Abstract excerpt

The increasing availability of diverse biobanks has enabled multi-ancestry genome-wide association studies (GWASs) to enhance the discovery of genetic variants across traits and diseases. However, the choice of an optimal method remains debated, due to challenges in statistical power differences across ancestral groups and approaches to account for population structure. Two primary strategies exist: (1) pooled...

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PMID: 40902600
DOI: 10.1016/j.ajhg.2025.08.006
PMCID: PMC12416762

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