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Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level

5 Nov 2019

Abstract excerpt

CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression data. Single-cell RNA sequencing and qPCR of dye-labelled antigen-specific cells identified large gene sets that were congruently up- or downregulated in...

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PMID: 31781096
DOI: 10.3389/fimmu.2019.02568

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