Article

Transforming summary statistics from logistic regression to the liability scale: application to genetic and environmental risk scores

2018-08-06

Abstract excerpt

1. 1.1. <h4>Objective</h4> Stratified medicine requires models of disease risk incorporating genetic and environmental factors. These may combine estimates from different studies and models must be easily updatable when new estimates become available. The logit scale is often used in genetic and environmental association studies however the liability scale is used for polygenic risk scores and measures of heritab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2bb050ce-7774-55f9-af98-9a7ab12c679c
DOI: 10.1101/385740

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transforming summary statistics from logistic regression to the liability scale: application to genetic and environmental risk scoresDOI 10.1101/385740Read

On the Transformation of Genetic Effect Size from Logit to Liability Scale.Semantic proximity Read

Liability-scale heritability estimation for biobank studies of low-prevalence diseaseSemantic proximity Read

Liability-scale heritability estimation for biobank studies of low prevalence diseaseSemantic proximity Read

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenomeSemantic proximity Read

A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained.Semantic proximity Read

A better coefficient of determination for genetic profile analysis.Semantic proximity Read

The contribution of genetic variants to disease depends on the ruler.Semantic proximity Read

Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution.Semantic proximity Read

Estimating disease heritability from complex pedigrees allowing for ascertainment and covariatesSemantic proximity Read

Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates.Semantic proximity Read

Transformation to estimate the causal effect in Mendelian randomization study with binary risk factor and outcome.Semantic proximity Read

Estimation of disease risk under bivariate models of multifactorial inheritance.Semantic proximity Read