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Article

A better coefficient of determination for genetic profile analysis.

Genetic epidemiology - 1 Apr 2012

Lee Sang Hong, Goddard Michael E, Wray Naomi R, Visscher Peter M

Abstract excerpt

Genome-wide association studies have facilitated the construction of risk predictors for disease from multiple Single Nucleotide Polymorphism markers. The ability of such "genetic profiles" to predict outcome is usually quantified in an independent data set. Coefficients of determination (R(2) ) have been a useful measure to quantify the goodness-of-fit of the genetic profile. Various pseudo-R(2) measures for...

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PMID: 22714935
DOI: 10.1002/gepi.21614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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