A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained.

doi:10.1371/journal.pgen.1001230

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Article

A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained.

PLoS genetics - 2 Dec 2010

So Hon-Cheong, Sham Pak C

Abstract excerpt

An increasing number of genetic variants have been identified for many complex diseases. However, it is controversial whether risk prediction based on genomic profiles will be useful clinically. Appropriate statistical measures to evaluate the performance of genetic risk prediction models are required. Previous studies have mainly focused on the use of the area under the receiver operating characteristic (ROC)...

Topics

Area Under Curve
Biostatistics
Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Humans
Models, Statistical
Predictive Value of Tests
ROC Curve
Risk Factors

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Identifiers

PMID: 21151957
DOI: 10.1371/journal.pgen.1001230
PMCID: PMC2996330

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