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Article

Transformation to estimate the causal effect in Mendelian randomization study with binary risk factor and outcome.

BMC bioinformatics - 27 Feb 2026

Lotfy Nesma

Abstract excerpt

BACKGROUND: In some GWAS studies, particularly those involving biobank data, linear regression is employed to obtain summary statistics on binary traits, while others report the log odds or odds ratios from the logistic regression of the genomic variants. However, some studies applied a transformation equation between logistic regression to linear regression. AIM: The current study aims to assess the performance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41761063
DOI: 10.1186/s12859-026-06388-1
PMCID: PMC13023191

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