The contribution of genetic variants to disease depends on the ruler.

doi:10.1038/nrg3786

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Article

The contribution of genetic variants to disease depends on the ruler.

Nature reviews. Genetics - 1 Nov 2014

Witte John S, Visscher Peter M, Wray Naomi R

Abstract excerpt

Our understanding of the genetic basis of disease has evolved from descriptions of overall heritability or familiality to the identification of large numbers of risk loci. One can quantify the impact of such loci on disease using a plethora of measures, which can guide future research decisions. However, different measures can attribute varying degrees of importance to a variant. In this Analysis, we consider and...

Topics

Genetic Diseases, Inborn
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Models, Statistical
Quantitative Trait, Heritable
Risk

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PMID: 25223781
DOI: 10.1038/nrg3786
PMCID: PMC4412738

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