Article
Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth.
Experimental cell research - 15 Nov 2020
Hu Feng, Huang Yimin, Semtner Marcus, Zhao Kai, Tan Zhoubin, Dzaye Omar, Kettenmann Helmut, Shu Kai, Lei Ting
Abstract excerpt
Aquaporin 1 (AQP1), a transmembrane protein that forms water channels, has previously been shown to facilitate growth and progression of many types of tumors by modulating tumor cell migration, proliferation and angiogenesis. Here, we determined the impact of AQP1 expression in the tumor environment on the progression of brain tumors. Primary microglia from wild type(WT) and AQP1 knockout(KO) mice were used to...
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