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Cross-Species Transcriptomic Integration Reveals a MIRO1-Mediated Macrophage–T Cell Axis in Glioma

2025-11-12

Abstract excerpt

Mitochondrial regulators are increasingly recognized for their influence on immune signaling within the tumor microenvironment (TME). In glioma, where immunosuppression limits therapeutic efficacy, we investigate how targeting the mitochondrial protein MIRO1 alters the TME. We combine single-nucleus RNA sequencing of murine gliomas treated in vivo with a MIRO1-binding compound and bulk RNA sequencing of human glio...

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Literature Corpus work
aa919146-a99e-5dfb-aed8-79f748dff75d
DOI
10.1101/2025.11.10.686781
Open publication

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Cross-Species Transcriptomic Integration Reveals a MIRO1-Mediated Macrophage–T Cell Axis in GliomaDOI 10.1101/2025.11.10.686781
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