Article

Hv1 proton channel is essential for splenic antibacterial defense and immune homeostasis during the chronic phase of traumatic brain injury in male mice

2026-08-05

Abstract excerpt

<h4>Background</h4> Traumatic brain injury (TBI) is increasingly recognized as a chronic condition with lasting systemic consequences. Beyond persistent neuroinflammation, long-term TBI disrupts peripheral immune homeostasis, increasing susceptibility to infection and organ dysfunction, particularly in older patients. The voltage-gated proton channel Hv1, expressed in microglia and peripheral immune cells, regula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7eff6a0-ec19-5035-9b72-11596e6035db
DOI: 10.64898/2026.07.31.742029

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hv1 proton channel is essential for splenic antibacterial defense and immune homeostasis during the chronic phase of traumatic brain injury in male miceDOI 10.64898/2026.07.31.742029Read

A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomesSemantic proximity Read

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity Read

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in GliomaSemantic proximity Read

Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injurySemantic proximity Read

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.Semantic proximity Read

An integrated analysis of gut microbiota and the brain transcriptome reveals host-gut microbiota interactions following traumatic brain injurySemantic proximity Read

The meningeal transcriptional response to traumatic brain injury and agingSemantic proximity Read

Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injurySemantic proximity Read

Amyloid precursor protein is a subunit of microglial Hv1 channels.Semantic proximity Read

Transcriptional activation of <i>Bmal1</i> drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stressSemantic proximity Read

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in miceSemantic proximity Read