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Article

Amyloid precursor protein is a subunit of microglial Hv1 channels.

Current opinion in immunology - 1 Jun 2026

Zhao Ruiming, Goldstein Steve An

Abstract excerpt

Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates neuroinflammation and contributes to a range of central nervous system pathologies. Our recent work shows that proton channels in microglia are formed by the co-assembly of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41780099
DOI: 10.1016/j.coi.2026.102751
PMCID: PMC13274435

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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