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Article

Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice.

The Journal of endocrinology - 1 Nov 2006

Kim Jung Han, Stewart Taryn P, Soltani-Bejnood Morvarid, Wang Luan, Fortuna Jennifer M, Mostafa Ola A, Moustaid-Moussa Naima, Shoieb Ahmed M, McEntee Michael F, Wang Yun, Bechtel Lawrence, Naggert Jürgen K

Abstract excerpt

The TALLYHO/JngJ (TH) strain is a newly established, polygenic mouse model for type 2 diabetes (T2D) and obesity, and we have previously reported some key physiological features of this model after the overt onset of diabetes. In the present work, we conducted a comprehensive phenotypic characterization of TH in order to completely characterize this new and relevant model for human T2D and obesity. We monitored...

Topics

Animals
Blood Glucose
Blotting, Western
Body Weight
Breeding
Cholesterol
Deoxyglucose
Diabetes Mellitus, Type 2
Female
Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucose Transporter Type 4

Insulin

Male

Mice

Mice, Inbred Strains

Muscle, Skeletal

Pancreas

Phenotype

Source

Identifiers

PMID: 17088413
DOI: 10.1677/joe.1.06647

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Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice.PMID 17088413Read ↗

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