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Modeling the spectrum of type 2 diabetes in mice.

Endocrinology - 4 Feb 2026

Grieco-St-Pierre Lili, Hoyeck Myriam P, Estall Jennifer L, Bruin Jennifer E

Abstract excerpt

Type 2 diabetes (T2D) is a heterogenous metabolic condition characterized by varying degrees of insulin resistance and β-cell dysfunction. Preclinical mouse models are essential tools to investigate the mechanisms of T2D pathogenesis and develop therapeutic targets; yet, researchers often fail to specify which aspects of the spectrum of human T2D phenotypes are being modeled. In this mini-review, we critically...

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Identifiers

PMID: 41527917
DOI: 10.1210/endocr/bqag005

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