Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel

Abstract excerpt

<h4>ABSTRACT</h4> In the human, there is a circadian rhythm in the resting heart rate and it is higher during the day in preparation for physical activity. Conversely, slow heart rhythms (bradyarrhythmias) occur primarily at night. Although the lower heart rate at night is widely assumed to be neural in origin (the result of high vagal tone), the objective of the study was to test whether there is an intrinsic c...

Topics

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• Arrhythmias, Cardiac
• Biological Clocks
• Cardiovascular Agents
• Circadian Rhythm
• Cyclic Nucleotide-Gated Cation Channels
• Disease Models, Animal
• Heart Rate
• Mice, Knockout

Identifiers and source

Literature Corpus work

2b5f2465-d0a2-5fb8-a876-bdafa46d0e0a

DOI

10.1101/684209