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Article

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

1 Jan 2012

Abstract excerpt

In the adult animal the sinoatrial node (SAN) rhythmically generates a depolarizing wave that propagates to the rest of the heart. However, the SAN is more than a simple clock; it is a clock that adjusts its pace according to the metabolic requirements of the organism. The Hyperpolarization-activated Cyclic Nucleotide-gated channels (HCN1-4) are the structural component of the funny (I(f)) channels; in the SAN...

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Identifiers

PMID: 22783204
DOI: 10.3389/fphys.2012.00240

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