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Article

Pacemaker channels produce an instantaneous current.

The Journal of biological chemistry - 15 Feb 2002

Proenza Catherine, Angoli Damiano, Agranovich Eugene, Macri Vincenzo, Accili Eric A

Abstract excerpt

Spontaneous rhythmic activity in mammalian heart and brain depends on pacemaker currents (I(h)), which are produced by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here, we report that the mouse HCN2 pacemaker channel isoform also produced a large instantaneous current (I(inst(HCN2))) in addition to the well characterized, slowly activating I(h). I(inst(HCN2)) was specific to expression of...

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Source

Identifiers

PMID: 11741901
DOI: 10.1074/jbc.M106974200

Genes

HCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pacemaker channels produce an instantaneous current.PMID 11741901Read ↗

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.Semantic proximity Read ↗

Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization.Semantic proximity Read ↗

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.Semantic proximity Read ↗

Pacemaking by HCN channels requires interaction with phosphoinositides.Semantic proximity Read ↗

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological PacemakerSemantic proximity Read ↗

Separable gating mechanisms in a Mammalian pacemaker channel.Semantic proximity Read ↗

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.Semantic proximity Read ↗

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.Semantic proximity Read ↗

Differential contribution of HCN1 and HCN4 to the synchronisation of sinoatrial pacemaker cellsSemantic proximity Read ↗

HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.Semantic proximity Read ↗

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse ModelsSemantic proximity Read ↗

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