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Article

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2020

Comelli Martina, Meo Marianna, Cervantes Daniel O, Pizzo Emanuele, Plosker Aaron, Mohler Peter J, Hund Thomas J, Jacobson Jason T, Meste Olivier, Rota Marcello

Abstract excerpt

Heart rate variability (HRV) is a measure of variation in time interval between heartbeats and reflects the influence of autonomic nervous system and circulating/locally released factors on sinoatrial node discharge. Here, we tested whether electrocardiograms (ECGs) obtained in conscious, restrained mice, a condition that affects sympathovagal balance, reveal alterations of heart rhythm dynamics with aging....

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Identifiers

PMID: 32886003
DOI: 10.1152/ajpheart.00379.2020
PMCID: PMC7654658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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