Article

A novel conceptual model of heart rate autonomic modulation based on a small-world modular structure and heterogeneous innervation of the sinoatrial node

2023-08-07

Abstract excerpt

The current theory of cardiac pacemaker rate modulation by the autonomic nervous system is based on the concept that a primary pacemaker cell or a group of cells in the center of the sinoatrial node (SAN) can change its AP firing rate within a broad range, driving respective myocardium contractions to commensurate body demands. Experimental data show, however, that pacemaker cells are extremely heterogeneous, with...

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Identifiers and source

Literature Corpus work: 9735f88f-4a87-55e6-944f-ccc4482015bd
DOI: 10.1101/2023.08.06.552167

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